Thanks, to all of you. This helps a lot. It seems it is about half and half. I have some people say never open seams, but my hand pieced, hand quilted is now 26 years old and seems to be holding up fine, with open seams.
I agree it is easier to nest the seams when to one side. I think it will just depend on how I am going to quilt it.
I also try to press to the dark side if really obvious. But sometimes for hand quilting, I have trouble getting through several seams, even with the stab method. My stitches are 10-11 to the inch, until I meet one of those nasty seams, and I am not good at the stab method of hand quilting, which for me is the only way to get through them. It is such a pain.