I am a huge fan of Janome, that being said, I have the 350E and love it. It has the USB port for hooking up to the computer for designs. It was the 4x4 and 5x7 sizes ant that is fine for what I do. I found it very user friendly. I have had mine for 2 years and my cost from the dealer brand new was $1,089. I tried a brother combo first and within a week knew that I didn't want a combo and that I wanted the larger hoop size as this one did the 4x4 only.
Having a dealer that you trust and can work with is very important. Then you will have the added investment of thread and stabilizer as well. I love mine.
I bought an external hard drive to read the cd's and hook up to my machine. No regrets here.