I have used bedsheets on every quilt ive done. No problem with handquilting, and absolutely no problem machine quilting lol, the sheets break the needles??? lol and punch holes in the fabric, i suppose if you are using a large needle, but i just use my regular 12 needle, and have not had any problems...think about it, the bedsheets get sewn in the factory don't they, hemmed and stuff :) :) :)