I am a former Buffalo resident. When ever I go back home there are two places I must stop at.
1. Favorite Fabrics - a board member here, an internet shop but they let you come a shop .... very good prices for the latest released fabrics. Wonderful staff! Do check the hours since they are an internet "store" they do not have traditional retail hours.
They are in Orchard Park... FYI you will think you are lost when you try to find it.. The first time I went I had to call from the parking lot to get to the right building. It is sooo worth the stop.
http://favoritefabric.com/
2. The Quilt Farm- its in a real barn that has been converted into a quilt shop, on both floors. Prices are not as favorable as Favorite Fabrics .. but it is a REALLY big traditional quilt shop. I typically do both in the same day , first Fav Fabrics , then The Quilt Farm. This one you will think you are lost as well since its really out on a farm area , no other retail in the area.
http://www.quiltfarm.net/
If my time was limited and I absolutely had to pick just one ---It would be Favorite Fabrics.