I have a preference for quilts that are reversible, especially if the quilting will be in an attractive pattern. And I had much rather have the back side have a large solid piece for the center framed by borders, than to have it pieced in a cross or striped pattern. That's because I think the bordered design looks better when/if it shows on a bed than a big cross does. Either way will stretch fabric that wasn't sufficient to back a whole quilt.
The borders on the back side should line up with the blocks or borders on the front side inorder for the quilting pattern to stay at its most attractive position.