Wow, there are a lot of us lefty quilters. I use the Fiskars rotary cutter with the blade on the "other" side, I use scissors righty, I use the lines on the cutting mat and rulers but not the numbers ( I do a lot of touching lines and counting...since I'm a special ed teacher it comes naturally!). My biggest problem is figuring out which direction things go together...don't know if that's a lefty problem or just me. I have a lot of trouble with left and right when following directions.