I switched the olfa blades to the other side and buy either universal scissors or left handed ones. I also have a left handed "finger press." I just read my ruler carefully, though there are left handed rulers now.
Generally, I haven't had too many problems compared to using a computer or some other "right-handed" items. It is more of a problem with other handicrafts like knitting and crocheting. Mine came out lumpy, so I gave that up. Sewing is not really so handed, which is nice.
We are also "the only ones in our right minds (LOL)." :)