I tend to do QAYG section by section, rather than block by block. The quilt below was so much easier to do in narrow sections than it would have been in a large piece. While I normally use a busy fabric that hides the sections, in this case, I wanted to use up Thimbleberries fabrics that wouldn't play well with other fabrics.
http://pic20.picturetrail.com/VOL252.../216336111.jpg
http://pic20.picturetrail.com/VOL252.../216336114.jpg