Yes you can!! When I made this quilt (link follows), I used the wrong fusable stuff. I had to quilt all the edges of the ultra-suede. For really small pieces, I covered with a water soluble stabilizer and stitched over it, so that the little pieces wouldn't come back up with the needle. I later washed the quilt to block it for quilt shows, so the stabilizer disappeared.
Take your time. This is doable!!
http://wheatridgestudios.blogspot.co...-in-woods.html