just make the quilt= when it's done (quilted and bound) put it in the washer with cold water and a color catcher- the fabrics will be fine- you would be amazed by the THOUSANDS of quilts with a few fabs pre=washed- many not-
the quilts turn out fine-
if you are worried about any of the eye spy squares bleeding you could dampen the square and press a white paper towel on it- if color comes off- it should be washed.