I had a hysterectomy when I was 32, due to endometriosis. I went on hormones at 34 and took them for almost 30 years. No problems and I am now 75 and so healthy. Am so glad I took them. I was in Dr today for physical and Dr said I am in such good shape for my age. Take no meds except calcium and vit. E Never suffered any sweats, hot flashed etc. Guess I was very lucky.