My house has been like that a lot. I hand-raise orphan newborn kittens. And my biggest help is my big boy Loki. He is over 80lbs. and has NEVER injured one of the babies. Oh, and he thinks that they are HIS babies. He has gone so far as to steal the babies from me and hide with it in the bedroom.
It is really funny because my girl Freya had no interest in the babies at all.