Took a low dose of estregen prescribed by my doctor, sometimes changed nightgowns in the middle of the night, sometimes blessed out the family, put weight on around my middle, DIDN'T get cancer from the drug, didn't get wrinkles as long as I took the drug, didn't get depressed as long as I took the drug. Hated to give it up but got worried about taking it more than 20 years. When I quit taking it my face wrinkled, my weight bloomed and my spine curved!