I know we just had this conversation earlier this week..but I can not find my post..
the majority said YES....especially if you have a smoker in the same block as you, you have any kind of animals in the house...etc...
Since I prewash my fabrics before making the quilt, I generally do not worry about washing it again before it leaves the house...depends on how much handling it gets!
If I do wash it, I make sure the recipient knows that..and does not wash it again!
If I don't wash it, I let them know that as well!