I think any quilt that is made by a human who *cares* about the quilt and where it is going to end up should be considered hand-made.
When one of my sons was in third grade his class had a unit that somehow related to quilts... maybe a unit about the frontier or something, and the teacher sent home a request asking that if anyone had made a quilt that they come in for a show-and-tell. I brought the first quilt I ever made--I found a pattern I liked in a book, decided I wanted to change it "just a bit," ended up changing it a lot (fabric colors, size, extra borders, etc.), cut the fabrics myself--sometimes several times, as I was still figuring things out, pieced it all on a machine, machine quilted it to a pieced backing, and then hand-sewed the back of the binding on. It is a masterpiece that took months to make, even though it is an extra-large lap-size. I still consider it one of my best and if I had to rescue just one of my quilts from disaster, that would be it.
One of the students asked, "did you make it by hand or is it machine made?" I was floored--it had never occurred to me that anyone, even an 8-year-old, might consider a quilt sewn at home to be anything less than hand-made. After I picked my jaw up off the floor and finished stuttering, I explained that not all, but *most* quilts made since the sewing machine became common are at least pieced on a machine, and that while I did quilt the top on a machine, it was my hands that guided it through the machine; so YES, it was hand-made.
On the other hand, I'm not sure how the quilts sold in retail stores are manufactured on a step-by-step basis, but even if it is a human guiding the fabric through a machine in a sweatshop somewhere, I don't consider them hand-made. That person doesn't care what happens to the quilt, had no part in selecting the pattern or fabrics, can't change the finished product if the urge strikes, and might as well just be a piece of machinery themselves... and probably will be replaced by one, eventually. They don't care if they are sewing quilts, or shirts, or tents--so anything made in a factory can never be hand-made.
A self-serving definition? I don't know... I must give at least some extra credibility to a completely hand-guided needle-and-thread quilt, because I have a fantasy of someday sewing an entire quilt by hand... but I seriously doubt that is ever going to happen! Even if I got started today in my 30s, I'd never finish it during this lifetime.... too many quilts to make, too little time to wield a needle for anything but binding! :)