Deb,
Don't be depressed over this...it happens to ALL quilters. It's a matter of thinking through the situation and how it will make you happy. Did you prewash? Are the wrinkles small enough that they will make the quilt look "aged"? Are the puckers really as big as you think or is it the agony of "perfection" dogging you?
Hang the quilt over a rod and let it "hang ease" a little to see if that helps any. Then think about the length of quilting stitches, are they so tight they are pulling your fabric? What foot are you using? Is it maybe displacing the fabrics? (I've had that happen and it really gets my goat!!!!) And get the spray, it's worth the cost to help keep everything in place.
WE all know you can do this and make it a work of art. Put perfection behind you and think about WHO you're doing this wonderful work for, the depression will go away with relaxing and enjoyment!!
Hugs,
Sharon