I bought a portable sewing table ( not big but it was sturdy enough) and tried to do most of my cutting at home.. Altho I did some on e the road. I had a foldable cutting board that I laid out on the bed when I needed to cut ( rotory cutters I used the dining table/mat. We had a 45 ft with 2 slides.... gave me alot more room. ( they come with 4 slides now, even 2 bedroom models are available). We always towed a vehicle with us. I've made everything from purses, wedding dresses, bridemaid dresses, quilts, civil war reenactment hoop dresses to crib sheets while traveling.
I bought platic drawer systems to go underneath in the storage bays for my fabric/supples. much easier than unloading totes and searching for the right one... each draw had it's labels for supples ( I did this for Motor home supplies, oil, tools, etc too)I added a velcro strap to the drawers to help hold them closed. If bad weather was pending, I could bring a select cabinet of drawers in, add the wheels and I could sew for days with out concern for weather.. then stored the wheeled plastic cabinet under the dining room table at night.....
U just need to be creative and a bit organized.... but it is VERY doable... I loved every minute of it.... the quilt s shops we found along the way.... sigh.....
good luck