I am in San Diego and can recommend all the LQS that have been suggested. If you are out in East county add Cozy Quilt shop in El Cajon.
For food would depend on what you are looking for. There are wonderful resteraunts in all pice ranges. I would suggest:
World Famous on the beach in Pacific beach.
If you are visiting Balboa park Prado is very good. Prado is a Cohn family resteraunt and all there places are excellant and you can google them and see them all.
My favorite is 3rd Corner in Ocean Beach but they have one in Palm Springs also.
For casual lunch try Pt. Loma seafood at the fishing docks.
Feel free to PM me if you have any questions.
I would love to get together too if you want to do that.