I have used 505 on large quilts (big queen) and liked it. Generally do some SID to hold it all in place and then go back to working from the middle out (but mostly because I want to get the hard part done first -- once the whole thing has been SID it shouldn't shift).
I think you should experiment with a small piece, however, if you're planning to hand quilt at all. My concern is that it could make it harder to needle through.