If you go to Niagara Falls, then you might want to go to Letchworth Park in the Finger Lakes area.
If you go through Pennsylvania, there's always Lancaster - a great area with lots of stuff to see there and in the surrounding areas. Of course, it's also the home of a great quilt show and lots of Amish/Mennonite stuff to see.
If you are going through Massachusetts, there are the Berkshires. We get off the highway at Pittsfield (great outlet mall at the exit) and then go to Lenox and nearby towns. The Norman Rockwell Museum is worth a visit!