Boy, I'm glad I didn't ask and just jumped in and quilted my first KING sized quilt on my machine! Yes, it's a domestic - a Singer Futura II I bought in 1976. I did just fine! I had to shove and scrunch and push, but it worked just fine! I did SID, using a decorative stitch actually, very few problems. I did do a fancy border stitch, and while it's not nearly professional nor show worthy, it's fine for my bed, which was it's intended use!
After that, I jumped right in and did a full size quilt - again, SID using a decorative stitch. It was a D9P also, and it came out just fine.
So, don't be discouraged! If I can do it, anyone can! I am seriously going to try some FMQ on my next one, which will probably end up full sized - I'm not using a pattern at all on this one - just kind of making it up as I go. The blocks so far are 15x17 and I only have 3 finished. I'm doing 4 across by 5 down, and haven't decided whether or not I'm putting borders on it.
Oh, and I'm a pinner. Haven't quite figured out spray basting yet, may give it a shot on this one.