I have the cutest quilt design that looks like puzzles pieces.
As far as the quilt....it all depends. I have a son with aspergers ( which is on the spectrum)
They love tactile fabrics. A variety would be good. However if it's just about awareness you can use the puzzle pieces. If you want to earn lots of money you may just make a quilt that appeals to everyone....in everyday colors. ....idk? Just a thought.