As long as it's water soluble the glue will be fine. I stopping using fusible webbing cos I didn't like the stiffness it created and my quilt wasn't soft. I believe over time and washing the applique gets softer but I want my quilts to be cuddly as soon as they're finished. I just dab with glue stick to hold in place while I stitch round. I'm not a big fan of applique but I've put hearts and butterflies on baby quilts and with my grandchildren wanting their names on book bags and notebook covers it the way to go as far I'm concerned.