I have done a queen size on my home machine. It wasn't the easiest thing to do and the thing I found that was the most helpful to me was the exact opposite of what the general instructions are for this type of quilting. Most instructions will say to roll the quilt up and put clamps on it and on and on. I found it very heavy to move around this way so I undid the rolls and just tossed the quilt on the table and bunched it up a little bit right around my sewing area and this one area of the quilt moved freely without the entire quilt having to move around all at the same time. This saved alot of pressure on hand gripping and on the ammount of drag the quilt had on the table. Hope this helps.
peace
EDIT: Nice monster!