How do you feel about the drive? Are you comfortable on the highway? That's the only consideration I have. Leave very early in the morning so you won't be traveling after dark and you should be fine. All those things you need to do at home will be there when you get back. So go and enjoy. No cooking, no cleaning, just relaxing. The Quilt museum is worth the trip.
Plan to send almost a whole day at Hancock's, it is mind boggling. We have never made it to Eleanor Burns shop because we stay to long at Hancock's and have to head back. One of these years we will have to start at her shop.
I think there is only one or two other shops in Paducah, so you will be safe if you survive Hancock's.