I've quilted it on my longarm and it quilts beautifully and it quilted easily. The quilt had a regular pieced cotton top and minky as a backing. The quilt also had a batting. The only thing to remember if you are loading onto a frame is to put the minky on the rollers so the least amount of stretch in the minky is going from roller to roller. I quilted it with regular cotton thread in a medium density edge to edge pattern.
I haven't tried minky to FMQ on my regular machine so I don't know about how that would be.