Maybe you could have some photographs printed onto fabric and use these as squares, then hand sew the sashings. Or make appliqued blocks that show highlights of family vacations and other memorable events that your children will recognize. Include ribbons and awards the kids won, print certificates from science fairs, etc. I think it depends on how old your children are. You could include boy scout badges or college diplomas. You might make one using baby pictures from several generations, or school pictures ,etc.
Whatever you do, I hope you have a lot of pleasure in making it and your family has a lot of pleasure in treasuring it. Best wishes for your improved health.