If you mean for machine quilting, I would basically do one half at a time. I would leave about 4 inches or one block width unquilted along the centers. I would then stitch the two section fronts together, trim and butt the batting together and use the iron on batting tape to connect the batting. I would then carefully lay the backing fabric flat and hand stitch the center seam with invisble ladder stitching. I would then quilt the center section that is unquilted and finish the edge....or send it out to be long armed. The biggest I've attempted to quilt on my machine is twin size.