I have done it a few times. The fleece is a little stretchy so you have to be careful if you try to actually quilt it. I quilted one and tied the other. Even if it is too warm to wrap or cover the baby in it; they can still use it as a play mat on the floor. My most recent baby quilt was made just with that purpose in mind. It is denim & flannel--denim for the floor and flannel for the baby side. Her parents are slobs and I wanted a heavy duty baby quilt--LOL.