For large quilts I use Grandma's quilting frame. Pin the backing to the fabric-wrapped board and stretch them out using chairs for legs. Smooth the batting out, then the top. Roll 2 sides toward the center and start pinning in the center, unrolling the sides and smoothing as I go. Works great and I can do it in the living room or over the top of my bed or in the garage. When everything is pin basted together I take the quilt off the frame and go to my DSM to quilt. The frame is just 4 1x2 boards that lay along the wall under my bed when I'm not using them, and 4 large "C" clamps that store with my other tools.
Grandma used her frame to hold the quilt for hand quilting, but I don't have room to keep the frame set up for days on end. I love having it to use. Makes me feel like she and I are quilting together.