I've done several I Spy quilts for little ones and never had a request for just girlie or just boy, or just pinks, etc. Kids love variety. I Spys are great fun and learning tools for matching, identifying shapes, colors, objects and critters. They are even useful as speech therapy quilts. Since the quilt is for your granddaughter i suggest you ask her parents if you feel you need to, but put in whatever you think she'd like. Sometimes adults get hung up on themes. Make what you'd like to- from your heart.