Oh my goodness YES. It has been over 20 years since I was able to go, but a memory I will carry always.
BE SURE YOU PLAN ON SEVERAL DAYS - Just to see the beautiful quilts & vendors w/exciting NEW things. But if you are in a position to also be able to take some of the classes offered (by well known instructors) try to take the extra time to do so. One of the years I went to it, a friend & I went 2 days early & took a few classes.
Here are a couple of links that may help you find some info about the show & area:
http://www.quilts.com/newHome/index.php
http://www.texasbob.com/travel/tbt_quilts_houston.html
Hope you are able to attend - it will be a wonderful journey.