For me it was early menopause at 29. Finally gave in and went on HRT because I could not stand it any longer. Have been on HRT for 38 years now but still cannot get off of it totally. Gradually reduced dosage and taking a vegetable based HRT. I would love to be off the meds but will stay with them as long as necessary. And my DH would appreciate I would stay with it until/unless I HAVE to stop taking.