I believe frame quilting is easier for anyone as PaperPrincess stated since it is more natural--moving the pen versus moving the paper. I like both methods however the constant hunching over the machine & wrestling with the fabric to fit it through the throat was more than my damaged shoulder could take. Even sewing rows together or borders on bed size quilts is a problem on a bad day.
Loading small quilts, wallhangings, tablerunners, etc. on a frame is a pain so those I still do on the sewing machine unless I have several that I can load on one backing fabric--like a set of placemats or 2 simple baby quilts.