I've traveled with my cat, quite easily. She rides in her pet carrier, that I've padded with a soft towel. When I got to the motel, I brought her into the room, brought in the litter box and let her out. She knew immediately where the box was, and used it. Most motel rooms these days (I think) have the underside of the bed blocked off so she couldn't get underneath and impossible to retrieve. I'm lucky, in that she's quite content and doesn't meow the entire way. That'll depend on how content your son's kitty is.