Have not read all the posts but when we moved from NC to FL and back 7 months later, we put our two cats in separate cages and the vet gave us "pee pads" for the bottom of the cages. It was a 8 - 10 hour trip and the cats never went. Once we were on the road for maybe 60 minutes, they settled in and mostly slept or rested. We had a litter box all ready for them when we got to the house. Oh and we offered water and a bit of food a couple of times when we stopped but they were not interested. Somehow they survived both trips. Not sure I did though. I also would not let a cat roam around the vehicle while driving. They could get under the foot of the driver and cause a big problem.