theoretically, any size machine is usable on a frame. the question is this: where does the needle face? if it faces like a regular machine, then you have to run it in the usual position. you can obviously get a much larger roll of quilted fabric under the arm, but facing that way you can't use it on a frame. to do that, it would have to sit on the side of the frame and....what? it can't reach all the way across. also, industrial or not, you still have to push all that stuff around.
now, if it faces the same way as a quilter's longarm, then yes. as long as the sled and rails are long enough AND the space between the take-up roller and the front roller are far enough apart to accommodate the base of the machine, then what you actually have is an industrial quilting machine.
what kind of frame do you mean?