i've made lots of quilts with cottons on the top and fleece backs- some i've used batting in, a couple i did not- it is up to you =
use a regular sharp or universal needle-
i recommend poly thread instead of cotton.
smooth the fleece= don't stretch it when you put the sandwich together- or you could tie it- that works well too with fleece.
it is not any more difficult to use than any other fabric.. a little thicker- you might need to adjust (loosen) your tension a little- but you may not have to- i've never had to- fleece quilts up beautifully. just baste well-either with pins every 4" or with needle and thread-- and smooth it--don't stretch it.