my first quilt was made from leftover home decor fabrics (it was a self-designed Chevron pattern so it was all strips cut by hand - didn't know anything about quilt making at that time. and I pressed the seams open.) but my now 6 year old quilt has held up just fine. I will say I do prefer the cotton fabrics over the home decor fabrics as far as cutting and sewing but yes, you can use home decor fabrics in quilts.