I used the American Chain pattern from quilterscache
http://www.quilterscache.com/A/AmericanChainBlock.html
I ironed freezer paper on the center rectangle and mailed it to all invitees with very SPECIFIC instructions on how to sign their name or write a brief note in #2 pencil. I used DMC embroidery floss to hand embroider the sentiments I received. (you found me that summer at the pool with the kids, embroidering away!)
I planned WELL in advance and recieved them ALL back. The finished quilt was hanging behind the cake at the party. My MIL loved it. What was extra special was that 3 of her close friends had passed away after sending me their blocks. She was in tears when she read all the notes. The quilt hangs at the top of her staircase and to date, she has lost many more of her friends/family.
It was not hard to do. Advance planning was key AND I prequilted the borders and attached them similarly to the quilt as you go method.
Also, some of our family had newborns and we had them use fabric paint and copy the footprints onto their rectangles--kids are now in high school! LOL
Good luck..