What a great time!
I am envious. I only get to one show a year, if that. The best advice is to wear good walking shoes, take a credit card and a big tote, and don't forget a bottle of water. Pace yourself. There is so much to see, both from the vendors and the exhibitors, you wouldn't know where to turn. If you have projects in mind, take yardage requirements and snippets of any fabrics you plan to use. If you are on a tight budget, try to keep your expenditure totals in mind as you go along; it's so easy to keep buying because, if there are vendors from afar, you may see great fabrics that are not available in your LQS and you'll want to buy them all. At least I do.
But mostly, have fun. Think of all of us who would love to be there with you! (And remember where you parked.)