it really depends on the quilt- what it's for- and how far off they are-
no one is perfect- did you know in the Amish community they will turn something upside down or make a mistake on purpose- because only god can create perfection?
if it doesn't take away from the look- most people would not even notice if a point is not perfect- only if you are entering it in a show= having it judged --is it a big deal