I have RA, too...among other problems. I've been on Humira for about five years now and am in my late 60's. For me, it's been a MIRACLE drug as I could not walk, keep house for my hubby, cook, clean, take care of our pets..not even type on my PC. Thank goodness I CAN do all those things. But the RA happened overnight, and my wrists were damaged (you can read my profile to see other problems). I LOVED to hand quilt and had done it for years...especially at night while my hubby watched TV. I can put quilt pieces together on my sewing machine and make very nice tops. However, I usually make full, queen and king size...too big for machine quilting. I certainly cannot afford to have them machine quilted, nor could I afford a quilting machine! (Gasp!) I don't have any special tricks to make quilting easier. I use two tables put together to lay out my backing, batting and quilt top...and I do it the old-fashioned way...PIN>>>PIN>>>PIN using large safety pins. Now...I could NOT do this until after I was on Humira for about six months. My quilting stitches have turned from beautiful to messy, so I hand-tied my last two with yarn. But now I am finishing a quilt. I used STIFF wrist supports that I bought from the drugstove. I've learned I cannot quilt fast as I once did, nor can I expect perfection. My stitches are longer than before and uneven when I hand-stitch. I cannot afford to have my tops machine quilted, nor could I afford a machine. :-(( Are you taking Humira or another TNF blocker? I take that plus Methotrexate. At the beginning of this disease, I wanted to die...because of the hideous pain and the inability to do my housework or even take care of my husband. So I am happy the Humira worked for me. Quilting is VERY hard on the wrists, and I am thinking of buying a stand-alone frame when I save up the money. It's hard for me to hold the round quilting frame...and the quilts are just too heavy. I quilted for two hours this afternoon, got very little done and was BUSHED afterward. And yes...I know about the lack of energy. There are days when I HAVE to take a nap with the cats in the afternoon. Fatigue is part of this disease. All I can say right now is quilt for maybe one hour at the most...use wrist supports and think about getting a frame. Those hoops are SO hard to hold when one has RA. Do keep in touch.