just doing it as invisibly as possible is all you can strive for. i use the self threading needles, slip one into the interior layers of the quilt, weaving back and forth and up and down to catch as many layers as possible. leave the needle in place while you hold firmly and pull the thread into the self threading groove and then pull inside. this can be done even when the end is very short. backstitch when you can, keep traveling as much as possible to have as few ends as possible.....