I think it would be do-able.....my first thought tho, (not to put a damper on the idea) was this.... when it comes time to match the edges for binding it, how would one go about that?... but I guess a wide border ...at least on one side would help with that. Another would be the quilting....an all over meander, or patterned quilt design would probably work, but you couldn't stitch in the ditch on one side and expect it to land in the same spot on the other, right? LOL
I guess I thought of that because I am still stuck in the ditch....been practicing my free motion tho!