As to the washing/cleaning question, it depends on each of the fabrics that you use. If they are all machine washable, and you construct the quilt with this in mind you should be fine.
Stretchy fabrics should probably be backed with interfacing, the same with thinner fabrics or those that easily fray.
Where you may run into issues is if you use washable fabrics, and your embellishments (buttons, other adornments...) hang up on the stitching, or the finish comes off of them. You may want to choose these items carefully. Also, check to see if they are dry cleanable too, if you choose to go that route
You may also want to shorten your stitch length or use a very small, narrow zig zag stitch (this stitch will allow the seams to give a bit more without breaking). These quilts tend to be heavy, and the agitation in a machine may stress the seam lines.
I would also make sure the decorative stitching will hold up to stress too, maybe sew them onto a scrap of fabric and then tug pretty good on the fabric and see if they hold up