I have hand quilted a few things, but now have rheumatoid arthritis and can't do it anymore, so I machine quilt most anything. The largest I've ever done on my Janome is an oversized queen sized quilt for my bed. I do mostly meander or SID on throws and larger items. I have a Grace Frame, but don't use it, even though it's set up in a room in my finished basement. I have trouble standing long enough to make much progress at one time.