I have done big stitch quilting on pre-printed baby quilt panels. I just follow the outline of the object in the panel (if it had a teddy bear on it outline the teddy bear for example). They turn out really cute and are fun to do on a pre-printed panel. They work up much faster than regular hand quilting and are great for charity quilts. I have used pearl cotton and a large needle. I haven't tried embroidery floss but imagine it would work well also.