There is one in Ankeny. My absolute favorite is in Ames, about 20 miles north of Ankeny. It's a pretty big store. Here is my list:
Ankeny - Quilters Cupboard, 706 SW 3rd St, 515-963-8758, quilterscupboardiowa.com
Ames - Quilting Connection, 238 Main St, 515-233-3048, iaquilts.com
Clive - Creekside Quilting, 9926 Swanson Blvd, 515-276-1977, creekside-quilting.com
West Des Moines - Quilt Block, 325 5th St, 515 255 1010, iowaquiltblock.com
There may be more in surrounding towns, but the Des Moines area only has the last two. If anyone else knows of more, I'd love to hear about it.