I would cut a square opening in paper or cardboard and see how large a block it would require to get the motifs and then use the large blocks as a focal Might just put sashing around it.
Several years ago I used a jungle print that was printed in large motifs. I just cut it into squares and did an attic window type sashing around it. I didn't try and cut specific motifs but just let the cut fall where it would.
You almost don't know that it was cut without fussy cutting from one fabric. I made mock attic window sashing in which the mitre wasn't cut and stitched but folded at the corner. It was very easy to make and quick.